Glutamine restriction and green tea (EGCG)
Cutting glutamine starves the tumor's second fuel; EGCG from green tea blocks the enzyme glutamate dehydrogenase and so blocks glutamine use.
Glutamine addiction is real, a live pharma target; EGCG inhibits glutamate dehydrogenase in cells.
No human trial has shown green tea, EGCG, or dietary glutamine restriction changes a cancer outcome.
Targeting glutamine metabolism as a potential target for cancer treatment, PMC 2025, An alternative mechanism of glutamate dehydrogenase inhibition by EGCG, PMC 2025, Targeting cancer hallmarks with EGCG, PMC 2024
PENDING Targeting glutamine metabolism as a potential target for cancer treatment, PMC 2025. PENDING An alternative mechanism of glutamate dehydrogenase inhibition by EGCG, PMC 2025. PENDING Targeting cancer hallmarks with EGCG, PMC 2024.